Health Condition 1: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Asian Healthcare Foundation
Applied for DBT Wellcome India Alliance Funding
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for T2DM cases are as follows: (1) Self-reported diabetes or medical record/report listing T2DM as a condition. (2) Treatment naïve (i.e., no self-reported use of diabetes medication) to reduce confounding effects of drugs on the biomarkers, (3) Individuals with high risk of developing diabetes and with family history of diabetes will be enrolled. In parallel, we will recruit age, ethnicity and gender-matched healthy volunteers without T2DM as controls.
Exclusion criteria
Exclusion criteria: Patients who have diabetes related-complications or other co-morbidities will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Generation of islet transcriptome and proteome datasets from Indian individuals with T2DM 2. Identification of functional, cellular, and/or molecular characters in Indian pancreata for biomarkers. 3. Development of critical mass trained in translational research of islet biology and T2DM in India. 4. Development of an interdisciplinary research team in collaboration with national and international institutes to study endocrine pancreasTimepoint: outcome 1 - 3 years outcome 2 - 3 years outcome 3 - 5 years outcome 4 - 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of molecular pathways of type 2 diabetes in IndiaTimepoint: 4 years | — |
Countries
India
Contacts
Public ContactMitnala Sasikala
Asian Healthcare Foundation
Outcome results
None listed