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A study to compare between two different routes of a drug called lignocaine in smooth post operative recovery after general anaesthesia.

A comparative study between intravenous and subglottic instillation of lignocaine for blunting of stress response to tracheal extubation after general anaesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050634
Enrollment
100
Registered
2023-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Subglottic instillation of Lignocaine (Group A).: At the conclusion of the surgery residual neuromuscular blockade will be reversed with injection Glycopyrrolate(6mcg/kg) and injection

Sponsors

Tuba Tufail
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of ASA 1 and 2 physical status. 2. Patients between 16 to 60 years of age of either sex. 3. Patients able to comprehend and willing to participate. 4. Patients scheduled for elective surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients refusal to participate. 2. Patients with known contraindications or sensitivity to the study drug. 3. Patients with pregnancy, morbid obesity and history of sore throat. 4. Patients with requirement of postoperative ventilation.

Design outcomes

Primary

MeasureTime frame
Changes in Haemodynamic parameters namely Hear Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP).Timepoint: Before Induction, at the time of administration of study drug, just before extubation then 1, 3, 5 and 10 minutes post extubation.

Secondary

MeasureTime frame
Cough, sore throat, Laryngospasm.Timepoint: Till 2 hours Post extubation.

Countries

India

Contacts

Public ContactTuba Tufail

Indira Gandhi Institute of Medical Sciences

drhussain72@yahoo.co.in9473376853

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026