Evaluation of propofol priming in hypertensive patients for induction of general anaesthesia

Evaluation of effect of priming in controlled hypertensive patients induced with propofol undergoing elective surgery under general anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050586

Enrollment

Registered

2023-03-10

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10-I16- Hypertensive diseases Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: inj Propofol: Group 1 will receive Drug: inj Propofol Dose : 0.5mg/kg Frequency : once before induction of General Anaesthesia Route : Intravenous Duration: One time Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age group 18-60 years of either sex with controlled hypertension (ASA 2 Blood pressure <140 / 90 mmhg taking antihypertensives medications for at least 8 weeks.) scheduled for elective surgery under general anaesthesia will be included in the study.

Exclusion criteria

Exclusion criteria: Patients with: 1) History of allergy to study medications 2) Anticipated difficult airway 3) BMI more than 30kg/m2 4) Pregnancy and lactating women 5) Who refuse to participate in study

Design outcomes

Primary

Measure	Time frame
To access hemodynamic changes in controlled hypertensive patients when propofol priming is applied before induction of general anesthesia.Timepoint: Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure will be observed at following intervals - 1) Baseline 2)Immediately after premedication 3)Just after priming dose of propofol 4) 2 mins after priming dose of propofol 5) Immediately after induction of general anaesthesia 6) 3 mins after induction of general anaesthesia. 7) Immediately after Intubation.	—

Measure

Time frame

To access hemodynamic changes in controlled hypertensive patients when propofol priming is applied before induction of general anesthesia.Timepoint: Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure will be observed at following intervals - 1) Baseline 2)Immediately after premedication 3)Just after priming dose of propofol 4) 2 mins after priming dose of propofol 5) Immediately after induction of general anaesthesia 6) 3 mins after induction of general anaesthesia. 7) Immediately after Intubation.

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Secondary

Measure	Time frame
Any other side effects associated with propofolTimepoint: within 24 hours after administration of propofol.;To calculate the induction dose requirements of propofol with priming. Timepoint: Immediately after Induction	—

Countries

India

Contacts

Public ContactDr Chhavi Saini

Pt BDS PGIMS Rohtak

drmayuriyadav@gmail.com9599912334

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026