Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: Active Transcranial Direct Current Stimulation (tDCS): The participants will receive stimulation current at 2mA for 20 min with ramp up of 30 sec and ramp down of 30 sec in a single ses
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Between age 18-55 years 2. Either gender 3. Right-handed individuals 4. Patients fulfilling the Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM 5) criteria for the diagnosis of MDD 5. Ability to read Hindi or English language 6. Willing to give informed consent 7. Medication naïve or Treatment free from prior 2 weeks or on a stable standard antidepressant regimen {including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MOAIs) or tricyclic (TCAs)} with no change in treatment 4-weeks prior to tDCS intervention 8. HAMD score >= 24 (severe depression)(Chistyakov et al., 2010; Goodman et al., 2006)
Exclusion criteria
Exclusion criteria: 1. Chronic medical or neurological illness (previously diagnosed) 2. Lifetime substance use disorder (excluding tobacco or caffeine) (as per DSM-5) 3. Suffering from or any psychiatric illness other than MDD 4. Not cooperative for testing 5. Past history of significant head injury 6. Known case of intellectual disability 7. Known or suspected pregnancy or currently lactating 8. Head metal implants 9. Subjects with significant suicidal risk upon clinical assessment 10. Any history of seizure 11. Previous history of receiving any brain surgical procedures 12. Implanted metal in their body 13. Electrical or magnetic stimulation on brain in the previous three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inter-group differences in change in scale scores (HAMD-17, MADRS and CGI).Timepoint: At baseline before beginning tDCS session and then after 10 and 20 sessions as well as after 4 weeks of last tDCS session | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in parameters obtained in EEG, fNIRS and MRI for correlation to symptom improvementTimepoint: At baseline before beginning tDCS session and then after 20 sessions and after 24 weeks of last tDCS session | — |
Countries
India
Contacts
Public ContactRohit Verma
All India Institute of Medical Sciences
Outcome results
None listed