Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Effect of Motor evoked potential measurement with 33% and 50% Nitrous oxide during spine surgeries: Patient will be shifted into the operating room and standard ASA monitors will be att
Sponsors
Department of Neuroanaesthesia and Critical Care, CNC, AIIMS, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status I and II, undergoing spine surgery under general anaesthesia, patient undergoing surgery in prone position, Surgeries requiring IONM monitoring, Patients willing to provide their voluntary written informed consent for participation in the study
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate 2. Patient of age less than 18 years and more than 60 years 3. ASA physical status III, IV 4. Patients with poor muscle power preoperatively (2 and lesser power) 5. Patients with paraplegia/quadriplegia 6. Patient allergic to any anaesthetic drugs used in the study 7. Patients with uncontrolled diabetes or hypertension 8. Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in amplitude and latency of MEP with different concentrations of nitrous oxide will be noted. Baseline readings will be recorded in all patients to see for significant decrease, if present, when nitrous oxide is switched on within the same group. The readings of T0-T4 will be compared amongst the 3 groups to check for significant changes between amplitude and latency with different concentrations.Timepoint: amplitude and latency readings of MEP from T0 to T4 will be noted. T0 baseline Then nitrous oxide started at desired concentration. MEP at T1 time of incision, T2 just before spinal instrumentation, T3 1 hour after T2, T4 at closure | — |
Secondary
| Measure | Time frame |
|---|---|
| The dose of propofol in mg/kg/hour with different concentrations of nitrous oxide will be noted. This will be done by noting total duration of surgery and amount of propofol (mg) used at the end of the surgery.Timepoint: The amount of propofol taken at the start will be noted. The total propofol consumed in each group at the end of surgery in each group N0, N33 and N50 will be noted and compared | — |
Countries
India
Contacts
Public ContactDr Niraj Kumar
AIIMS, New Delhi
Outcome results
None listed