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Evaluating intracanal medicaments to reduce microbial count in root canal and inflammation reduction in tooth infection - Randomized controlled trial

CLINICAL INVESTIGATION OF ANTIMICROBIAL EFFICACY AND RESOLVIN E1 IMMUNOEXPRESSION USING CHITOSAN, N- ACETYL CYSTEINE AND CALCIUM HYDROXIDE INTRACANAL MEDICAMENTS IN APICAL PERIODONTITIS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050533
Enrollment
60
Registered
2023-03-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: N - Acetyl Cysteine (1gm/1ml): DOSE:20mg FREQUENCY: Once ROUTE OF ADMINISTRATION:local application inside the root canal using lentulospiral DURATION OF INTERVENTION: 7 days placement i

Sponsors

Subiksha Kannan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Single-rooted 2. Pulp necrosis and apical periodontitis 3. Presence of one root canal.

Exclusion criteria

Exclusion criteria: 1. Patients who used antibiotics or antifungal medications in the past three months. 2. Root canal treated teeth 3. Any systemic disease 4. Periodontal pockets deeper than 4 mm 5. Teeth that could not be adequately isolated with a rubber dam 6. Acute apical abscess

Design outcomes

Primary

MeasureTime frame
Reduction of microbial loadTimepoint: 3 months—

Secondary

MeasureTime frame
Level of RvE1 in periapical tissuesTimepoint: 3 months—

Countries

India

Contacts

Public ContactSubiksha kannan

SCB Dental College & Hospital

amitjena@yahoo.com9437836499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026