Health Condition 1: K701- Alcoholic hepatitis
Conditions
Interventions
Intervention1: corticosteroids: standard steroid dose of oral prednisolone 40mg once daily for 28 days
Control Intervention1: corticoteroid: a tapering dose of oral prednisolone 40mg once daily of tap
Sponsors
AIG Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: WIth MELD score >21 and/or mDF >32 Patients with infection at baseline will be included if they have controlled infection.
Exclusion criteria
Exclusion criteria: 1)Age 70 years 2)Active Infection 3)Acute Kidney Injury (creatinine >1.5 mg/dl) 4)Recent / ongoing bleed 5)Active peptic ulcer disease 6)Hepatocellular carcinoma, portal vein thrombosis or hepatic venous outflow tract obstruction 7)Patients with concomitant other liver diseases including hepatitis B, C, NAFLD 8)Patients with HIV 9)Patients who are no willing to provide consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of infectionTimepoint: at day 28 and day 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in severity scoreTimepoint: in both groups - at Day 4,Day 7,Day 28 and Day 90;Compare the adverse events in each groupTimepoint: At Day 90;Compare the incidence of acute kidney injury in each groupTimepoint: At Day 90;Compare the incidence of mortalityTimepoint: at 90 days in both the groups;Compare the number of responders in both the groupsTimepoint: At Day 7;Compare the source, site, and outcomes of infectionTimepoint: At Day 90;To compare the proportion of patients requiring readmissions in each groupTimepoint: at day 90 | — |
Countries
India
Contacts
Public ContactAnand V Kulkarni
AIG Hospitals
Outcome results
None listed