Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: ketamine-propofol combination: Ketamine 0.5mg/kg and Propofol 0.5mg/kg of actual body weight in separate syringes will be given sequentially through an intravenous route in bolus before
Sponsors
All India Institute of Medical Sciences, Raipur
Eligibility
Inclusion criteria
Inclusion criteria: 1) Adult patients >18 years of age. 2) BMI >18.5 and & 3) Patient needing intubation in ICU
Exclusion criteria
Exclusion criteria: 1) Known intracranial pathology 2) Continuous sedative intravenous infusions for past 24 hours 3) Known severe psychiatric illness 4) Known drug allergy to any of the study drug 5) Known egg allergy 6) Known contraindications to any of the study drug 7) Cardiac arrest patients 8) Pregnant women 9) HR >160 or 10) SBP >180mmHg or 11) DBP >120mmHg or <30mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Change in Mean Arterial Pressure 2) Intubation Difficulty ScoreTimepoint: From baseline, immediately before drug administration (before intubation) to every minute till 10 minutes post-drug administration (post-intubation). | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital mortalityTimepoint: At 28 day;ICU free days provided patient is not readmitted within 24 hours of ICU dischargeTimepoint: After 24 hours of ICU discharge;New onset vasopressor useTimepoint: Within half an hour of administration of study drug;Ventilator free days provided that patient is not re-intubated within 48 hours of extubationTimepoint: After 48 hours of extubation | — |
Countries
India
Contacts
Public ContactDr Chinmaya Kumar Panda
All India Institute of Medical Sciences, Raipur
Outcome results
None listed