None listed
Conditions
Interventions
Intervention1: Carbetocin: Carbetocin 100 mcg single i.v. bolus would be given over 1 minute on delivery of the foetus and the clamping of the umbilical cord.
Control Intervention1: Oxytocin: Oxytocin
Sponsors
PDU Govt Medical College Rajkot
Eligibility
Inclusion criteria
Inclusion criteria: High risk pregnant patients posted for elective cesarean delivery under spinal anaesthesia of ASA Grade III and IV with 35-40 weeks of gestation, Multiple pregnancies, Previous cesarean scar, Presence of uterine fibroids, Previous myomectomy, Presence of placenta previa, Past history of PPH
Exclusion criteria
Exclusion criteria: Hypertension, Preeclampsia, Cardiac diseases, Renal diseases, Liver diseases, Epilepsy, Neuromuscular diseases, Severe anemia, General Anaesthesia, Women with history of hypersensitivity to carbetocin/oxytocin, Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy of Oxytocin and Carbetocin in terms of intraoperative blood loss, additional uterotonic needed and adverse effects if any in caesarean delivery with high risk of post-partum haemorrhage. To compare the hemodynamic effects of Oxytocin and Carbetocin (effects on heart rate and blood pressure) Timepoint: Heart rate and blood pressure noted before skin incision, after 1 minute, 3 minutes, 5 minutes, at the time of skin closure, after 2 hours, after 12 hours. Uterine tone noted at time of delivery and after 3 minutes, 6 minutes, 9 minutes, 12 minutes, 2 hours, 12 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Demographic data 2)Uterine tone 3)Additional uterotonic used 4)Additional side effectsTimepoint: 1)Maternal Age(years) and Gestational Age(weeks) 2)Likert Scale at time of delivery, after 3 minutes, after 6 minutes, after 9 minutes, after 12 minutes after 2 hours, after 12 hours(Likert scale 0-4, 0-floppy,1-soft, 2-poorly contracted, 3-well contracted, 4-hard rock) 3)Additional uterotonics used 4)Nausea, Vomitting, Flushing, Tachycardia, Hypotension, Headache, Chestpain | — |
Countries
India
Contacts
Public ContactDr Kalrav Rawal
PDU Govt Medical College,Rajkot
Outcome results
None listed