None listed
Conditions
Interventions
Intervention1: Almonds: - Food intervention: Almonds
- Amount to be consumed per day: 56grams
- Duration: 16 weeks
- Route of administration: oral
Control Intervention1: Traditional cereal pulse based
Sponsors
Almond Board of California
Eligibility
Inclusion criteria
Inclusion criteria: Age 20 years to 50 years, Both male and female, BMI 18.9 to 25 kg/m2, no nut allergies, willing to participate in the study, fasting blood glucose levels between 100 to 125 mg/dl, post-prandial blood glucose levels between 140 to 199 mg/dl, HbA1c level between 5.7 to 6.4, no comorbidities such as thyroid, diabetes, chronic kidney disease, alcoholic liver disease, or any known case of cardiovascular disease, not taking medications (steroids and beta-blockers, antibiotics) known to influence metabolism and appetite, not be a chronic alcohol dependent or chronic tobacco consumption
Exclusion criteria
Exclusion criteria: Pregnant women and lactating mothers, not willing to participate in the study, BMI more than 25 kg/m2, nut allergies, fasting blood glucose less than 100 mg/dL and more than 125 mg/dL, random blood glucose more than 200 mg/dL, HbA1c levels less than 5.6 and more than 6.5, other comorbidities such as thyroid, diabetes, chronic kidney disease, alcoholic liver disease, or any known case of cardiovascular disease, on medications (steroids and beta-blockers, antibiotics) known to influence metabolism and appetite, chronic illness, chronic alcohol dependent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1cTimepoint: 16th week | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric parameters ( body weight, body height, BMI, waist circumference, neck circumference and hip circumference ) Dietary assessment (24 hr dietary recall) Physical activity assessment (PAL levels)Timepoint: baseline, 8th week, 16th week;Blood pressure (SBP, DBP),Timepoint: baseline, 8th week, 16th week;GLP-1Timepoint: Baseline,Endline;Glycemic control (FBS, PPBS) Fasting Insulin, HOMA IR Timepoint: baseline, 8th week, 16th week ;Gut microbiota composition (Lactobacilli spp & Bifidobacteria spp.) Short chain fatty acid composition (SCFA)Timepoint: baseline, 8th week, 16th week;Inflammatory markers (IL-6, hs CRP), S creatinine, S ureaTimepoint: baseline, 8th week, 16th week;Lipid profile (TC, TG, HDL, non-HDL, LDL, VLDL)Timepoint: baseline, 8th week, 16th week;Thyroid levels (TSH, T4) Liver function markers (SGPT, SGOT, GGT, s. bilirubin and s. protein albumin) Timepoint: baseline, 8th week, 16th week | — |
Countries
India
Contacts
Public ContactDr Pramila Kalra
Ramaiah International Centre for Public Health Innovations
Outcome results
None listed