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injection of cocktail Analgesics for pain control in Total knee replacement

Effect of Cocktail Analgesia on early functional recovery after Bilateral simultaneous Total Knee Arthroplasty - a Randomised Placebo Controlled Split body Non-inferiority Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050408
Enrollment
40
Registered
2023-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee Health Condition 2: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Cocktail of analgesics: 0.5% of 20 ml ropivacaine, 2 ml of 60 mg ketorolac and 1 ml of adrenaline, and the volume will be made up to 35 ml mixing it in normal saline and injected at the

Sponsors

All India Institute of Medical Sciences, Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients posted for simultaneous single staged B/L TKA 2. More than one compartmental primary OA with pain interfering with their ADL 3. KL Grade 3/4 4. ASA grade 1 and 2

Exclusion criteria

Exclusion criteria: 1. Any patient with previous knee surgery 2. Extra-articular knee deformity 3. Any spine disorder which may interfere with mobilization 4. Revision TKA cases 5. Previous history Septic Arthritis knee

Design outcomes

Primary

MeasureTime frame
To quantify pain scores after bilateral total knee replacement with peri-articlar cocktail analgesiaTimepoint: 6, 12, 24, 48,72 hrs after surgery—

Secondary

MeasureTime frame
Changes in other clinical outcomes following cocktail analgesia â?? quadriceps strength, ROM, and time taken to mobilise â?? TUG testTimepoint: 24, 72 hrs after surgery—

Countries

India

Contacts

Public ContactArghya Kundu Choudhury

All India Institute of Medical Sciences, Rishikesh

arghyakunduchoudhury@gmail.com8013006295

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026