A Comparison of nebulisation with dexmedetomidine and nebulisation with 4% lignocaine to prevent response during intubation

To determine the efficacy of nebulised dexmedetomidine and nebulised lignocaine in attenuation of hemodynamic response to laryngoscopy and intubation in patients undergoing elective surgeries under general anaesthesia: A prospective, randomised comparative study.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Observational

Source

CTRI

Registry ID

CTRI/2023/03/050403

Enrollment

Registered

2023-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Interventions

Control Intervention1: Dexmedetomidine nebulisation: Group D-patient will receive nebulization of dexmedetomidine 1mcg/kg mixed with normal saline to a total volume of 5ml given over 10 minutes Contro

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA I and II patients of either sex. 2.Patients aged between 18 to 50 years. 3. Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: 1.History of allergy to study drug. 2.Renal and hepatic dysfunction. 3.Cerebrovascular disease, bronchial asthma, ischemic heart disease, seizure disorders. 4.Patients on drugs like antidepressants, antipsychotics, anxiolytics or anticonvulsants. 5.Patients with difficult airway. 6.Patients in whom Cormack and Lehane grade are 3 or 4, duration of laryngoscopy >30 seconds, unexpected difficulty in ventilation or intubation

Design outcomes

Primary

Measure	Time frame
To determine the efficacy of nebulised dexmedetomidine and nebulised lignocaine in attenuation of hemodynamic response to laryngoscopy and intubation in terms of Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP)Timepoint: 0,1,3,5,10 minutes	—

Secondary

Measure	Time frame
side effects if anyTimepoint: 0,1,3,5,10 minutes	—

Countries

India

Contacts

Public ContactDr Nadia Rose

Rajarajeswari medical college and hospital

dr.nadia.rose@gmail.com9513454567

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026