Health Condition 1: C50- Malignant neoplasm of breast Health Condition 2: C15-C26- Malignant neoplasms of digestive organs Health Condition 3: C51-C58- Malignant neoplasms of female genital organs Health Condition 4: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx Health Condition 5: C45-C49- Malignant neoplasms of mesothelial and soft tissue Health Condition 6: O- Medical and Surgical Health Condition 7: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: tranexamic acid: 1 gm (2 vials
each vial 500mg) of Tranexemic acid is injected into 100 ml of normal saline and it is given via intravenous infusion once 15 minutes before the onset of surgery.
Control Intervention1: placebo: 100 m
Sponsors
nil
Eligibility
Inclusion criteria
Inclusion criteria: all cancer patients undergoing surgeries for breast gyanecology, Head &neck ,GI, soft tissue sarcoma& others
Exclusion criteria
Exclusion criteria: Patients with coagulopathy(activated partial thromboplastin time >50 s or International normalised ratio >1.5, platelets 1.2 mg/dl), Liver dysfunction, Known allergy to tranexamic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Operative blood loss 2. Blood transfusion rates Timepoint: baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of hospital stay 2. Length of stay in ICU 3. DVT 4. Pulmonary embolism Timepoint: 5 days | — |
Countries
India
Contacts
Public ContactDEEPA
Tirunelveli Medical college
Outcome results
None listed