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Does dexmedetomidine use decrease the tendency for stroke following aneurysm coiling?

Effect of intravenous dexmedetomidine usage on the incidence of post-procedure vasospasm in patients undergoing endovascular aneurysm coiling - a comparative study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050361
Enrollment
50
Registered
2023-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I671- Cerebral aneurysm, nonruptured Health Condition 2: I602- Nontraumatic subarachnoid hemorrhage from anterior communicating artery Health Condition 3: I604- Nontraumatic subarachnoid hemorrhage from basilar artery Health Condition 4: I600- Nontraumatic subarachnoid hemorrhage from carotid siphon and bifurcation Health Condition 5: I601- Nontraumatic subarachnoid hemorrhage from middle cerebral artery Health Condition 6: I606- Nontraumatic subarachnoid hemorrhage from othe

Interventions

Intervention1: Intravenous infusion of dexmedetomidine as an adjunct anaesthetic / sedative agent: Patient undergoing endovascular procedures will be administered intravenous dexmedetomidine infusion

Sponsors

Dr Mathew George
Lead Sponsor
Dr Prem Nair
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients who have been diagnosed with intracranial aneurysms who are planned for elective endovascular therapy by coiling under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients who are known to be allergic to dexmedetomidine. Patients who are on ventilatory support pre-procedure and unable to give consent for the study.

Design outcomes

Primary

MeasureTime frame
Post-procedure intracerebral vasospasm as asessed by drop in conscious level, development of new focal deficit or as assessed by transcranial doppler criteriaTimepoint: Vasospasm will be evaluated upto 48 hours post procedure

Secondary

MeasureTime frame
To assess the degree of disability in patients undergoing aneurysm coiling or stenting at the time of dischargeTimepoint: 1 month following the procedure

Countries

India

Contacts

Public ContactDr Neethu Rebecca Isaac

Amrita Institute of Medical Sciences and Research center

mathewgeorge@aims.amrita.edu9447841795

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026