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Retraining of balance, nerve glide exercises, resistance training, and instruction in daily living skills are effective treatments for chemotherapy-induced peripheral neuropathy in cancer survivor

Efficacy of balance re-education, neural mobilisation, resistive and activities of daily living training on chemotherapy induced peripheral neuropathy in cancer survivors: Two arm randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/03/050356
Enrollment
28
Registered
2023-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C801- Malignant (primary) neoplasm, unspecified

Interventions

Intervention1: balance re-education, neural mobilisation, resistive and activities of daily living training: 1. Balance Re-education a. Standing on one foot b. Sit to stand c. Medio-lateral and Ant

Sponsors

AMAR JYOTI INSTITUTE OF PHYSIOTHERAPY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - Age 18-60 years had primary diagnosis of cancer - Given chemotherapeutic regimen for atleast 1 cycle - Both Male and female - All types of cancer - Had a karnofsky performance status >= 70 - Should be able to walk 3 meters - Have at least 1 neuropathy symptom according to CIPN assessment tool (CIPNAT).

Exclusion criteria

Exclusion criteria: - Hereditary peripheral neuropathy .{ e.g., Charcot-marie-tooth disease} - If they had other chronic neuropathic disease likes Diabetic Neuropathy, Multiple Sclerosis, Neuritis etc. - Orthopaedic problem that affect balance (e.g. ACL reconstruction) - Vestibular disorder and visual acuity problem - Chronic inflammatory demyelinating polyneuropathy - Concomitant disease like diabetes, renal insufficiencies - Prior history of alcohol abuse - Lower limb amputee - Use of walking Aid - Treatment with antiepileptic drugs, antidepressants and major analgesics.

Design outcomes

Primary

MeasureTime frame
Modified total neuropathy score A 6 -item tool that combines patient report of subjective sensory and motor symptoms, deep tendon reflexes, manual muscle testing of distal muscles, pin sensibility, and quantitative vibration thresholds. â?¢ 0 -24 points, higher score indicates worse neuropathy. Timepoint: will be assessed at baseline and after 3 weeks

Secondary

MeasureTime frame
functional independence measureTimepoint: The test/Questionaire will be assessed at the baseline and at the end of 3 weeks. (Pre and Post);timed up and go testTimepoint: The test/Questionaire will be assessed at the baseline and at the end of 3 weeks. (Pre and Post);UNIPEDAL STANCE TEST â?¢ Patients were asked to stand barefoot on the limb of their choice, with the other limb raised so that the raised foot was near but not touching the ankle of their stance limb. â?¢ Prior to raising the limb, the subject was instructed to cross his arms over the chest. â?¢ The investigator used a stopwatch to measure the amount of time the subject was able to stand on one limb. â?¢ Time commenced when the subject raised the foot off the floor ended when the subject either (1) used his arms (ie, uncrossed arms) (2) used the raised foot (moved it toward or away from the standing limb or touched the floor) (3) moved the weight-bearing foot to maintain his balance (ie, rotated foot on the ground) (4) a maximum of 45 seconds had elapsed (5) opened eyes on eyes closed trials. Timepoint: The test/Questionaire will be assessed at the baseline and at the end of 3 weeks. (Pre and Post)

Countries

India

Contacts

Public ContactDR NIDHI SINGH PT

AMAR JYOTI INSTITUTE OF PHYSIOTHERAPY

nidhi.singh2411@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026