comparision between the effect of bolus inj mephentermine and inj phenylephrine for management of hypotension during caesarean section performed under spinal anaesthesia

clinical study to compare the effect of bolus inj mephentermine and inj phenylephrine for management of hypotension during caesarean section performed under subarachnoid block

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/03/050191

Enrollment

Registered

2023-03-01

Start date

Unknown

Completion date

Unknown

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Control Intervention1: Mephentermine: DOSE OF 6 MG IV BOLUS WILL BE GIVEN WHEN THERE IS HYPOTENSION ( FALL IN MAP MORE THAN 20% ). RESCUE DOSE OF 3 MG WILL BE GIVEN IVBOLUS AFTER 5 MINS OF FIRST DOSE

Eligibility

Inclusion criteria

Inclusion criteria: 1. Full term parturient of age 20 -35 years. 2. American society of Anaesthesiologistsclass 1 and 2 3. Scheduled for caesarean section under subarachnoid block during the study period.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Below 20 years and more than 35 years. 3. H/O hypertension, preeclampsia, eclampsia,hyperthyroidism, any coexisting neurological , cerebrovascular, renal , metabolic, psychiatric, occulovascular disorder. 4. Having known fetal abnormalities and fetal distress.

Design outcomes

Primary

Measure	Time frame
to study and compare the onset of action , duration of action and haemodynamic parameters 9 SBP, DBP, HR , SPO2)Timepoint: immediately after SAB, at 1min ,2 min , 3 min ,6 min , 9 min , 12 min , 15 min , 20 min , 25min , 30 min , 40 min , 50 min, 60 min , 70 min, 80 min, 90 min	—

Secondary

Measure	Time frame
to study and compare theside effects of mephentermine and phenylephrineTimepoint: mmediately after SAB, at 1min ,2 min , 3 min ,6 min , 9 min , 12 min , 15 min , 20 min , 25min , 30 min , 40 min , 50 min, 60 min , 70 min, 80 min, 90 min	—

Countries

India

Contacts

Public ContactDr Shambhawi Tiwari

Peoples college of medical science and research centre

ph.anaesthesia@peoplesuniversity.edu.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026