Health Condition 1: I420- Dilated cardiomyopathy
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: nil: nil
Sponsors
Dr Nagpal Raghav Radhakrishan
Eligibility
Inclusion criteria
Inclusion criteria: LVEF equal to or less than 45% More than 3 months from ACS event Ischemic Cardiomyopathy patients who have undergone complete revascularization in the form of percutaneous coronary intervention or surgery more than 3 months prior to inclusion in the study Creatinine clearance of less than equal to 30 ml per min per m2 Patients on optimal heart failure therapy, beta blockers ARB ACE inhibitors aldosterone antagonists and or diuretics if tolerated
Exclusion criteria
Exclusion criteria: 1) Diabetes Mellitus 2) Recent ACS, 3) Ischemic cardiomyopathy patients who have not undergone complete revascularization 4) Coronary Revascularization ( percutaneous coronary revascularization or coronary artery bypass grafting) or valvular repair/replacement within 3 months prior to enrolment 5)severe infection 6) serious liver or renal functional failure eGFR 7) alcohol dependency or use of illicit drugs 8) pregnant or breastfeeding, possibly pregnant or planning to become pregnant in the study period (female patients only) 9) urinary tract or genital infection 10) history of hypersensitivity to the study drugs 11) severe ketosis, diabetic coma or precoma 12) ongoing or past history of pancreatitis 13) heart failure due to restrictive cardiomyopathy, active myocarditis, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease 14) symptomatic bradycardia or second or third degree heart block without a pacemaker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in E/e prime ratio between early mitral inflow velocity and mitral annular early diastolic velocity , from baseline to mean of 3-6 months follow upTimepoint: 0, 3-6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Area length ejection fractionTimepoint: 0, 3-6 months;left atrial volume and indexTimepoint: 0, 3-6 months;Left ventricular ejection fractionTimepoint: 0, 3-6 months;left ventricular end diastolic volume and indexTimepoint: 0, 3-6 months;left ventricular end systolic volume and indexTimepoint: 0, 3-6 months;LV contractility dp/dtTimepoint: 0, 3-6 months;LV mass indexTimepoint: 0, 3-6 months | — |
Countries
India
Contacts
Public ContactDr Raghav Nagpal
KMC Manipal
Outcome results
None listed