Health Condition 1: F54- Psychological and behavioral factors associated with disorders or diseases classified elsewhere
Conditions
Interventions
Intervention1: ketamine: injection of 5mg/kg of ketamine in multiple syringes by intramuscular route(50 mg/ml
max.4ml per intramuscular site)once.After injection,RASS score will be recorded at every 5 mins interval until primary end point is reached .i.e.RASS less than or equal to -1 or until 30 mins of sedat
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Age more than or equal to 18 years Patients with clinical diagnosis of severe agitation with Richmond Agitation Sedation Scale score of 3 or more
Exclusion criteria
Exclusion criteria: Attenders not willing to consent Pregnant females or breastfeeding females Patients with known allergy or hypersensitivity to drugs Known kidney or liver disease Known alcoholic disorder Contraindication to study medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time( in minutes) from study medication administration to adequate sedation defined RASS less than or equal to -1Timepoint: 30 minutes of sedation assessment period | — |
Secondary
| Measure | Time frame |
|---|---|
| Need for intubation Effect on acid-base gas analysis Effect on biochemical parameters Clinical outcomes Safety of study medications Need for rescue medicationsTimepoint: At every 5 mins interval for initial 30 mins then every 30 mins interval post drug administration till patient is in ED for need for intubation,safety of study medications,for rescue medications and for clinical outcomes.At baseline and at 30 mins for effect on acid base gas analysis and effect on biochemical parameters. | — |
Countries
India
Contacts
Public ContactDr MAGISHA VARDHANI R
AIIMS Rishikesh
Outcome results
None listed