Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: Dexmedetomidine is an α-2 agonist which has property of good anxiolysis, sedation and analgesic action.This study compares different doses of dexmedetomidine -0.5 mcg
Sponsors
Anna Mary George
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists (ASA) Physical Status 1 and 2 Age 18 â??59 years Posted for elective surgeries under general anaesthesia
Exclusion criteria
Exclusion criteria: Patients who are physically dependent on narcotics Those with a history of bronchial asthma, drug or alcohol abuse. Known drug allergy to either clonidine or dexmedetomidine, Cerebrovascular, neurologic, respiratory or ischemic heart disease (history of angina, previous myocardial infarction) Renal and hepatic dysfunction. Patients on alpha-blockers, antidepressants, anxiolytics, anticonvulsant or antipsychotics Any predicted difficult airway
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To arrive at an optimal dose of IV dexmedetomidine by comparing different doses of the drug with normal saline in terms of attenuation of haemodynamic stress response to laryngoscopy and endotracheal intubationTimepoint: Recorded at 1, 3 , 5 and 10 min after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the sedation after the drug infusion based on Ramsay sedation score.Timepoint: Recorded at 1, 3 , 5 and 10 min after intubation | — |
Countries
India
Contacts
Public ContactAnna Mary George
ST JOHNS MEDICAL COLLEGE,BANGALORE
Outcome results
None listed