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Evaluation of bupivacaine induced myotoxicity after giving ultrasound guided erector spinae block in patients undergoing modified radical mastectomy by measuring pre op and post op serum CPK levels

Evaluation of bupivacaine induced myotoxicity in ultrasound guided erector spinae block in patients undergoing modified radical mastectomy. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/050113
Enrollment
40
Registered
2023-02-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site Health Condition 2: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: Preoperative and Postoperative serum CPK levels in patients undergoing ultrasound guided erector spinae block using 0.25% bupivacaine posted for modified radical mastectomy: Preoperativ

Sponsors

Pt B D Sharma PGIMS ROHTAK MRU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Female patients aged 20-60 years with American Society of Anesthesiologists- physical status I and II, scheduled to undergo MRM for carcinoma breast under general anaesthesia (GA)

Exclusion criteria

Exclusion criteria: 1. Not willing to give consent 2. With infection at the needle insertion site 3. With known hypersensitivity to local anaesthetic agent 4. With bleeding disorder or on anticoagulant 5. With BMI > 30 kg/m² 6. With musculoskeletal disorder 7. With chest wall deformity 8. With pregnancy or lactation 9. With difficult airway

Design outcomes

Primary

MeasureTime frame
To measure serum CPK levels postoperatively in ultrasound guided erector spinae block in patients undergoing MRMTimepoint: To measure serum baseline CPK levels,at 6 hours ,at 24 hours postoperatively in ultrasound guided erector spinae block in patients undergoing MRM

Secondary

MeasureTime frame
1. Intra operative fentanyl consumption 2. Post operative pain score 3. Time for requirement of first rescue analgesia 4. Analgesic consumption in 24 hoursTimepoint: Pain assessment will be done post operatively using VAS at 0,1,6,12,18,24th hour after surgery.

Countries

India

Contacts

Public ContactDr Puneet Sharma

Pt. B.D. Sharma PGIMS ROHTAK

puneetsharma2308@gmail.com8442843361

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026