Health Condition 1: I509- Heart failure, unspecified
Conditions
Interventions
Intervention1: Corn Starch will be given as oral intervention: dosage of 10gms per day for 90 days
Control Intervention1: Not Applicable: Not Applicable
Sponsors
Narayana Hrudayalaya
Eligibility
Inclusion criteria
Inclusion criteria: • Age: 18-60 years • Have a heart failure in New York Heart Association class II and class III and class IV • Echocardiographically verified LVEF • Signed informed consent and expected cooperation of the patients for the treatment
Exclusion criteria
Exclusion criteria: • Treatment with antibiotics or probiotics within the last 3 months • Treatment with immunosuppression drugs within the last 3 months • History of high fibre in toleration • Malignancy of any cause, excluding basal cell sarcoma of the skin • Severely impaired kidney function (i.e., Estimated glomerular filtration rate • Impaired liver function (Alanine aminotransferase > 150 U/I) or Chronic liver disease • Ongoing Infection, including GI infection • Inflammatory Bowel Disease • Bowel obstruction • Post Colectomy • Active myocarditis, including Chagas disease • Pregnancy and planned pregnancy • Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcomes to be measured- potential prebiotic supplementation effects on gut microbiota The effect will be measured by correlating with gut microbiome profile, changes in biochemical parameters and correlating it with dietary questionnaire.Timepoint: 12 MONTHS | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The impact of prebiotics supplementation on cardiac left ventricular hypertrophy on heart failure with reduced ejection fraction (HfrEF)-Measured by analyzing changes in ECCO reports 2.The potential prebiotic supplementation effects on inflammatory stress indices, and liver function in individuals with heart failure with reduced ejection fraction- Based on changes in biological parameters 3.whether prebiotic supplementation will improve quality of life in individuals with heart failure with reduced ejection fraction (HfrEF)- Based on responses obtained from study participantsTimepoint: 12 MONTHS to 36 months | — |
Countries
India
Contacts
Public ContactDr Muralidhar K
Sri Devaraj Urs academy of higher Education and research
Outcome results
None listed