Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Injection Sugammadex: At the end of surgery,
Single dose of 2mg/kg,
Intravenously.
Control Intervention1: Injection neostigmine and glycopyrrolate / atropine: At the end of surgery,
Sponsors
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Children of 2 years of age to 12 years of age. 2) ASA Physical status 1,2 and 3 3) Those requiring general anaesthesia with endotracheal intubation for their elective surgical procedure.
Exclusion criteria
Exclusion criteria: 1) ASA physical status 4 2) Children with known or suspected co-existing neuromuscular disease, bleeding disorders, or kidney dysfunction 3) Patient shifted on ventilator to PACU
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Aims 1.To compare the time from the start of administration of neostigmine or sugammadex until a train-of-four (TOF) ratio of 0.9 (1st twitch paralysis) is recovered. 2.To determine the time between the start of antagonist administration (either neostigmine or sugammadex) and the recovery of a TOF ratio of 1.0. Timepoint: At 15 minutes after recovery from neuromuscular blockade | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Aims 1. To find out the incidence of postoperative recurrence of neuromuscular blockade, which is defined either as a decrease in the TOF ratio to below 0.9 after full recovery, or as a deterioration in the clinical signs of recovery from the block. 2. To find out the incidence of other adverse effects like bradycardia, tachycardia, laryngospasm, bronchospasm and increased respiratory secretions. Timepoint: Upto 1 hour after achieving TOF ratio of 1.0 | — |
Countries
India
Contacts
Public ContactDr Aarti Agarwal
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Outcome results
None listed