Comparison of lignocaine and dexmedetomidine in suppressing of cough reflex and hemodynamic response during tracheal extubation after supratentorial tumour surgery: A Randomized control study

Effect of intravenous lignocaine and dexmedetomidine on inhibiting cough during tracheal extubation after supratentorial tumour surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/02/050064

Enrollment

Registered

2023-02-24

Start date

Unknown

Completion date

Unknown

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles

Interventions

Intervention1: Lignocaine infusion(Group A) and dexmedetomidine infusion(Group B): In group (A) â?? Lignocaine 2%, 1.5 mg/kg made up to 20 ml will be given IV over 10 minutes before induction of anest

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with supratentorial tumors planned for excision 2. ASA- I or II 3. Age between 18 - 65 years.

Exclusion criteria

Exclusion criteria: 1. Use of angiotensin -converting enzyme inhibitors (ACE-I), beta blockers, digoxin, Î±2-agonist 2. Bradycardia (heart rate 3. Arterial blood pressure 4. Renal and hepatic insufficiency 5. Local anesthetic allergy 6. Coagulation abnormalities 7. Patientâ??s refusal

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of intravenous infusion of dexmedetomidine and lignocaine in attenuating cough reflex and hemodynamic response during tracheal extubation after supratentorial tumor surgery under general anesthesia.Timepoint: At the stoppage of anaesthetic gases to 15 min after extubation	—

Secondary

Measure	Time frame
1. Emergence time from general anesthesia 2. Extubation time 3. Consumption of intraoperative fentanyl 4. Amount of intra-operative Norepinephrine use 5. Modified Aldrete score (Post anesthesia care unit discharge criteria) 6. Time to first analgesia Timepoint: At the stoppage of anaesthetic gases to 15 min after extubation	—

Countries

India

Contacts

Public ContactDr V Sasikiran

AIIMS RAIPUR

Vskn1988145@gmail.com9544672804

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026