Health Condition 1: D330- Benign neoplasm of brain, supratentorial
Conditions
Interventions
Intervention1: Inj Dexemedetomidine: -Group D – will receive inj dexmedetomidine at 1 mcg/kg iv over 10 min after
which the dose will be reduced to 0.5 mcg/kg/hr.
Control Intervention1: Inj Fentanyl:
Sponsors
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES
Eligibility
Inclusion criteria
Inclusion criteria: -Patients aged between 18 and 65years of ASA I and II -Patients undergoing elective supratentorial craniotomy
Exclusion criteria
Exclusion criteria: -Patients in whom dexmedetomidine is contraindicated (second and third degree heart block), -Patients in whom ANI will be unreliable (patients with pacemakers, patients on drugs affecting sinus node, patients having arrhythmias). -Patients with liver and renal diseases. -Patients on gabapentinoids, tricyclic antidepressants and other analgesics -Patients posted for aneurysmal clipping -Patients with decreased sensorium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the magnitude of change and response time in ANI, SPI and hemodynamic parameters (HR and MAP) to various noxious stimuli between patients receiving OFA with dexmedetomidine and those receiving opioid analgesia with fentanyl for supratentorial craniotomies. (Response time is the time taken for the parameter to change maximally due to noxious stimuli from the pre-stimuli value, i.e. lowest for the ANI and highest for SPI, HR and BP) (Magnitude of change is the difference between highest/lowest value after stimulation as compared to baseline i.e. pre-stimuli value)Timepoint: Before starting analgesic drug infusion and after 5 min and 10 min of starting infusion. At Intubation, skull pin insertion, skin incision, first burr hole placement, and durotomy. | — |
Secondary
| Measure | Time frame |
|---|---|
| -To compare the magnitude of change and response timein ANI, SPI, hemodynamics with in the group -To determine and correlation between ANI and SPI in patients receiving opioid and OFATimepoint: Before starting analgesic drug infusion and after 5 min and 10 min of starting infusion. At Intubation, skull pin insertion, skin incision, first burr hole placement, and durotomy. | — |
Countries
India
Contacts
Public ContactSONIA BANSAL
National Institute of Mental Health and Neurosciences, Bengaluru
Outcome results
None listed