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Effect of Soluble Triggering Receptor Expressed on Myeloid cells â?? 1 (sTREM-1) and Tumor Necrosis Factor - alpha (TNF-α) in gingival crevicular fluid of health, generalized gingivitis and generalized stage III grade B periodontitis

Estimation and correlation of Soluble Triggering Receptor Expressed on Myeloid cells â?? 1 (sTREM-1) and Tumor Necrosis Factor - alpha (TNF-α) in gingival crevicular fluid of health, generalized gingivitis and generalized stage III grade B periodontitis - a cross - sectional study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/02/049980
Enrollment
45
Registered
2023-02-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: E119- Type 2 diabetes mellitus without complications Health Condition 3: E119- Type 2 diabetes mellitus without complications

Interventions

None listed

Sponsors

ARYA DEVI S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) Individuals with healthy periodontium. b) Patients with diagnosis of generalized gingivitis. c) Patients with diagnosis of generalized stage III grade B periodontitis. (Periodontal health, gingivitis and periodontitis definition will be based on the classification of Gingival and Periodontal Diseases as proposed in 2017 World Workshop) d) Patients with diagnosis of Type 2 Diabetes Mellitus ( HbA1c e) Presence of at least 20 natural teeth.

Exclusion criteria

Exclusion criteria: a) Patients with any systemic diseases other than Type 2 Diabetes Mellitus. b) Subjects who have undergone periodontal therapy in last six months preceding the start of the study. c) Individuals who have history of any antimicrobial or anti- inflammatory therapy in the last six months. d) Smokers. e) Pregnant, lactating and postmenopausal women.

Design outcomes

Primary

MeasureTime frame
To estimate and correlate the GCF levels of sTREM - 1 and TNF-α in subjects with health, generalized gingivitis and generalized stage III grade B periodontitis. Timepoint: At Base Line—

Secondary

MeasureTime frame
To explore the possibility of using sTREM -1 and TNF- α as a marker of inflammation in generalized stage III grade B periodontitis. Timepoint: At baseline—

Countries

India

Contacts

Public ContactARYA DEVI S

The Oxford Dental College

sunaina1096@gmail.com9845203336

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026