None listed
Conditions
Interventions
Intervention1: ACCELERATED HEPATITIS B VACCINE (GeneVac-B) SCHEDULE: HEPATITIS B VACCINE (GeneVac-B), 1ml intramuscular (preferably on left deltoid) given on day 0, day 10, day 21.
Control Interventi
Sponsors
SCHOOL OF TROPICAL MEDICINE
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 18 years and of all genders. Hepatitis B vaccine naïve persons People living with HIV attending out-patient department, ART centre Family members of patients attending hepatitis clinic at school of tropical medicine.
Exclusion criteria
Exclusion criteria: People with known hepatitis B virus infection. People with chronic kidney disease. People with malignancy or on chemotherapy. People with diagnosed autoimmune disease. People with severe HIV infection (WHO stage 3 and stage 4 disease), with CD4 count less than 200. People on steroids for more than 4 weeks or on any immunomodulator therapy. People received immunoglobulin in last 3 months. People having history of allergy to any vaccine or vaccine compound People with age more than 60 years Patients suffering from any acute illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To see development of immunogenicity i.e., Anti HBs antibody titre following classical hepatitis B vaccine schedule (0,1-month,6 month) and accelerated hepatitis B vaccine schedule (0, day 10, day 21)Timepoint: Anti HBs antibody titre will be done at baseline,2 month (only for accelerated schedule), 7 month following 1st dose of vaccine | — |
Secondary
| Measure | Time frame |
|---|---|
| complianceTimepoint: accelerated schedule: at 2 month standard schedule: at 7 months | — |
Countries
India
Contacts
Public ContactDr RUCHA KARAD
SCHOOL OF TROPICAL MEDICINE
Outcome results
None listed