Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Lignocaine: Lignocaine 1.5mg/kg will be given as intravenous bolus before induction of anaesthesia followed by lignocaine 1mg/kg/hour intravenous infusion throughout the surgery
Control
Sponsors
Amrita Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Age 18-70 years, ASA physical status 1 to 2, Both males and females, Patients with head and neck malignancy undergoing major surgeries requiring nasal intubation
Exclusion criteria
Exclusion criteria: Basal heart rate Cardiac arrhythmias, Heart blocks, congestive heart failure, cardiogenic shock, Liver disorders with AST/ALT >2-3 times normal or renal diseases with eGFR Hypersensitivity to lidocaine or amide-type local anesthetic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of heart rate response (HR) at 1 min following nasal intubation with opioid free general anaesthesia using intravenous lignocaine versus standard regimen in patients undergoing major head and neck surgeries.Timepoint: 1 min following nasal intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of heart rate before induction, after induction, 3and 5min after intubation in opioid free general anaesthesia versus standard regimen. Systolic, Diastolic and Mean arterial pressure (MAP) at the same time points, time required to intubate and number of attempts at intubation will also be compared.Timepoint: before induction, after induction, 3and 5min after intubation | — |
Countries
India
Contacts
Public ContactDr Sunil Rajan
Professsor in Anaesthesia, Amrita Institute of Medical Sciences, Kochi
Outcome results
None listed