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To determine the advantage of giving a smaller dose of the muscle relaxant drug atracurium prior to giving total dose by measuring the amount of neuromuscular receptors blocked using TOF monitor

QUANTITATIVE ASSESSMENT OF NEUROMUSCULAR BLOCKADE USING PRIMING PRINCIPLE WITH ATRACURIUM AND TRAIN OF FOUR MONITORING: A PROSPECTIVE RANDOMISED DOUBLE-BLINDED STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049888
Enrollment
60
Registered
2023-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Priming with neuromuscular agent ATRACURIUM: Assessing the extent of neuromuscular blockade by giving a priming dose -atracurium at 0.05mg/kg from calculated total intubating dose of 0.

Sponsors

SHEETHAL BABY SCARIA
Lead Sponsor
SAVITHA KS
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective surgery under General anesthesia requiring endotracheal intubation. 2. Patients aged between 18 and 59 years of either sex 3. Patients with American Society of Anesthesiologists (ASA) class I 4.Patients with BMI 18 -30kg/m 2

Exclusion criteria

Exclusion criteria: 1. Surgeries involving anticipated risk of aspiration 2. Patients with musculoskeletal disorders 3. Patients with anticipated difficult airway 4. Pregnant women. 5. Patients on aminoglycoside antibiotics

Design outcomes

Primary

MeasureTime frame
To compare the percentage of the neuromuscular receptors blocked at 3 minutes with and without priming in ASA I patients, undergoing elective surgeries under general anesthesia using TOF monitorTimepoint: 3 minutes—

Secondary

MeasureTime frame
intubating conditions using Cooper scoring systemTimepoint: at 0 minutes of intubation;time taken for zero twitch after bolus intubating dose of injection atracuriumTimepoint: time taken for zero twitch in minutes—

Countries

India

Contacts

Public ContactSHEETHAL BABY SCARIA

ST JOHNS MEDICAL COLLEGE HOSPITAL

DRSAVITHA_KS@YAHOO.COM9844638121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026