Health Condition 1: M170- Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention1: Platelets Rich Plasma with Alendronate: 3 doses of freshly prepared autologous 4 ml Leucocytes Poor Platelets Rich Plasma given for each knee at monthly interval with weekly 70mg of Al
Sponsors
Amit Kumar
Eligibility
Inclusion criteria
Inclusion criteria: Early stage of Degenerative osteoarthritis of knee 1.History of pain for the last 3 months according to the ACR criteria for knee osteoarthritis along with radiologic evidence of joint changes based on Kellgren-Lawrence criteria (including grades 1,2 and 3). 2.Mild radiographic OA of the medial compartment (medial tibiofemoral joint space 3.Mild varus malalignment by clinical examination
Exclusion criteria
Exclusion criteria: 1. Age 75 years 2. Any form of knee injection such as visco-supplements, ozone etc. in the preceding 3 months; 3. Having arthroscopic or open surgery in the past 6 months; 4. Having metabolic bone disease immunodeficiency, autoimmune disease, collagen vascular disease, or diabetes; 5. History of cancer; 6. Infection or inflamed lesion in the knee; 7. Platelet disorder or disease; 8. Use of anticoagulant or anti-platelet medication 10 days before injection; 9. Use of NSAIDs 2 days before injection; 10. Corticosteroid knee injection 3 weeks before injection or use of systemic corticosteroids 2 weeks before the injection; 11. Hemoglobin level less than 10 g/dL and platelets less than 150,000/microliter; 12. History of severe knee trauma; 13. Pregnancy and lactation; 14. Hypersensitivity to Bisphoshphonate 15. History of Renal impairment 16. Non-reactive for HIV, HBsAg and HCV by chemiluminscence 17. In diabetic patients Fasting blood sugar less than 110mg/dl and HbA1c less than 7.5 %
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of pain using Visual Analogue Scale, Improvement in Knee functional status by calculating Western Ontario and McMaster universities Osteoarthritis Index (WOMAC) Scores Timepoint: 6 and 12 months after completion of 3 months treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Conversion to Surgical OptionTimepoint: 2 years after completion of 3 months treatment | — |
Countries
India
Contacts
Public ContactAmit Kumar
Sanjay Gandhi Postgraduate Institute Of Medical Sciences
Outcome results
None listed