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Effect of Exercise in children with liver diseases

Effect of Exercise Based Regimen on Frailty in Children With Liver Disease -A Randomized Controlled Trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049869
Enrollment
40
Registered
2023-02-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K740- Hepatic fibrosis Health Condition 2: K768- Other specified diseases of liver

Interventions

Intervention1: Subject will receive 12 weeks of exercise with standard medical management (SMT): Subjects will be given exercise protocol Pre-exercise safety assessment: Careful assessment as per excl
especially Portal Hypertension, Cardiopulmonary status etc Frequency: Aerobic and Resistance Exercises for total 50 minutes/day for 2-5 days per week (see protocol) Aerobic exercises consist of Brisk

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children 9 - 18 years age with chronic liver disease & frailty score > 5

Exclusion criteria

Exclusion criteria: 1. Lansky play performance scale 2. Unable to do exercise under supervision on at least 2 occasions 3. Children on higher corticosteroid dose ( >0.1mg/kg/day) in last 12 weeks 4. Any degree of musculoskeletal involvement (myopathy/limb deformity/paraplegia) 5. Children with any cardiac disease 6. Children with neurological Wilson 7. Uncontrolled portal hypertension (persistent high-risk varices) Recurrent variceal bleed >= 2 8. Any degree of hemodynamic instability 9. Current hepatic encephalopathy (any grade) 10. Grade 3 ascites 11. Hepatic hydrothorax 12. Any degree of oxygen dependence 13. Severe or Very severe Hepatopulmonary syndrome (room air PaO2

Design outcomes

Primary

MeasureTime frame
Prevalence of Frailty in children with liver disease and Improvement in Frailty after 12 weeks of exercise therapy in children with CLD and Frailty.Timepoint: 12 weeks—

Secondary

MeasureTime frame
Decrease in myostatin levels after 12 weeks of exercise regimenTimepoint: 12 weeks;Decrease in the occurrence of significant events including HE, UGI bleed, SBP, AKI, new onset or increase in ascites, hospital stay and mortality.Timepoint: 3 months;Increase in skeletal muscle mass in Body composition analysis after 12 weeks of exercise regimenTimepoint: 12 weeks—

Countries

India

Contacts

Public ContactDr Vikrant Sood

Institute of Liver and Biliary Sciences

drvickyster@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026