Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Entropy guided desflurane administration: Desflurane concentration will be adjusted to keep entropy values in the range of 40â??60 during the procedure. To keep entropy values within th
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients, aged 18â??65 years 2. ASA physical status I, II or III 3. Elective major abdominal surgery with expected duration of more than 4 hours
Exclusion criteria
Exclusion criteria: 1. Absence of consent 2. History of any disabling central nervous or cerebrovascular disease 3. Hypersensitivity to opioids 4. Substance abuse 5. Treatment with opioids or any psychoactive medication 6. Deviation from the standard care of anaesthesia 7. Not extubating on table
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of desflurane used between MAC guided and entropy guided groups  Timepoint:  At the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive dysfunction in the two groups using Mini Mental State Examination scaleTimepoint: 1 day after surgery;Emergence agitation between the groupsTimepoint: At the end of surgery;Heart rate and Blood pressure during surgeryTimepoint: every 10 minutes during surgery;Mean end-tidal desflurane concentration Timepoint: at the end of surgery;Recall between the groups using Michigan awareness scale Timepoint: 1 day after surgery;Time of awakening Timepoint: at the end of surgery | — |
Countries
India
Contacts
Public ContactNeha Garg
INSTITUTE OF LIVER AND BILIARY SCIENCES
Outcome results
None listed