Health Condition 1: K745- Biliary cirrhosis, unspecified
Conditions
Interventions
Intervention1: ROTEM Based tests: The second group will undergo ROTEM based correction. ROTEM correction will be based on the following protocol :
EXTEM CT 80 sec - FFP will be transfused at 15 ml/k
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children 6m- 18years of age 2. Histologic or image proven liver cirrhosis of any etiology 3. Listed for an invasive procedure Procedures 1. Central venous cannulation 2. Haemodialysis catheter 3. Ascitic or Pleural tapping 4. EVL/EST 5. TIPPS 6. ERCP with sphicterotomy 7. PCD Insertion 8. Biopsies other than liver biopsy : INR >2.5 and/or PLT count 20,000/mm3- 50,000/mm3 9. Those listed for Liver Biopsy: INR >2 and/or PLT count 20-50,000/mm3
Exclusion criteria
Exclusion criteria: 1. Anti platelet or anti coagulant therapy in the previous 7 days 2. Patients with clinical evidence of DIC and/or active bleeding 3. Hemodialysis in the past 7 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of total component transfused (ml/kg) will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 1 day | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount of cryoprecipitate (ml/kg) transfused will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 1 day;The amount of FFP (ml/kg) transfused will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 1 day;The amount of Platelet (ml/kg) transfused will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosis.Timepoint: 1 day;The bleeding rate will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 5 day;The rate of transfusion reactions will be significantly less in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 5 day | — |
Countries
India
Contacts
Public ContactDr Seema Alam
Institute of Liver and Biliary Sciences
Outcome results
None listed