Comparative study between intravenous dexmedetomidine and intravenous magnesium sulphate in attenuation of cardiovascular stress response during laparoscopic appendicectomy under general anaesthesia

A comparative study between IV dexmedetomidine and IV magnesium sulfate in attenuation of cardiovascular stress response during laparoscopic appendicectomy under general anaesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/02/049761

Enrollment

140

Registered

2023-02-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K36- Other appendicitis

Interventions

Intervention1: Dexmedetomidine and magnesium sulfate: Both drugs given intravenously once in bolus dose over 15 minutes.dexmedetomidine given in 1ug/kg and magnesium sulfate in 30mg/kg in 100ml NS. Co

Eligibility

Inclusion criteria

Inclusion criteria: Patient with ASA-I,II, elective laparoscopy appendicectomy are included in the study

Exclusion criteria

Exclusion criteria: ASA-III,IV, Patient on vasopressor support,deranged liver and kidney function, known allergy to the given drugs are excluded from the study

Design outcomes

Primary

Measure	Time frame
To compare efficacy of Intravenous dexmedetomidine and intravenous magnesium sulphate in attenuating cardiovascular stress response of intubation and pneumoperitonueumTimepoint: 0, 1,3,5, 10 minutes of intubation	—

Secondary

Measure	Time frame
Sedation scale and post operative analgesia are better in intravenous dexmedetomidine than magnesium sulphate.Timepoint: 2hr,3hr, 4hr sedation score and analgesia score	—

Countries

India

Contacts

Public ContactALOK NATH SAMAL

VSS MEDICAL COLLEGE , BURLA, SAMBALPUR

patelpradipta@gmail.com9437062284

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026