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A clinical trial to study effect of Lignocaine given during surgery along with Pregabalin given prior to surgery in hypertensive patients undergoing abdominal surgeries under general anaesthesia

Preoperative Pregabalin with intraoperative Lignocaine infusion versus placebo for haemodynamic stability in hypertensive patients undergoing abdominal surgeries under general anaesthesia : A prospective randomized double blinded comparative clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049749
Enrollment
60
Registered
2023-02-15
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Pregabalin , Lignocaine: Group A is administered preoperative Pregabalin 150 mg orally 1 hour before anaesthesia induction,followed by intraoperative Lignocaine infusion 1.5 mg per kg

Sponsors

Manisha Roy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA II 2. Stage I hypertensive patients 3. Elective open abdominal surgeries 4.Willing to participate in study

Exclusion criteria

Exclusion criteria: 1. Patients sensitive to lignocaine. 2. Those suffering from cardiovascular disease. 3. Preoperative changes in ECG. 4. Patients on opioids or other pain medications. 5. Patients having epidural catheter insitu for perioperative analgesia. 6. Patients with functional bowel disorder.

Design outcomes

Primary

MeasureTime frame
To compare Mean Arterial Blood Pressure between 2 groups.Timepoint: 5 minutes before to 24 hours post end of surgery—

Secondary

MeasureTime frame
To compare heart rate between 2 groupsTimepoint: 5 minutes before to 24 hours post end of surgery;To compare intraoperative analgesic consumption between 2 groupsTimepoint: Time from skin incision to completion of surgery;To compare post operative analgesia and analgesic requirements between 2 grouosTimepoint: From time of completion of surgery to 24 hours post completion of surgery—

Countries

India

Contacts

Public ContactVinod Kumar Verma

Indira Gandhi Institute of Medical Sciences

drvvinodv@gmail.com8292000111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026