Health Condition 1: N186- End stage renal disease
Conditions
Interventions
Intervention1: Testing pre- and post- dialysis high-sensitivity troponin I in two different ultrafiltration settings commonly used in maintenance hemodialysis: All the patients will be dialysed using
Sponsors
Dr Namrata Rao S
Eligibility
Inclusion criteria
Inclusion criteria: Patients > 18 years of age, on maintenance hemodialysis > 3 months with UF removal rates of > 13 ml/kg/hour in > 3 occasions in the screening month and not receiving any UF profiling in the screening month
Exclusion criteria
Exclusion criteria: Active infection, hospitalization during screening month, unstable angina, NYHA Class IV heart failure, noncompliance to dialysis schedules, any requirement of > 4 dialysis sessions/week in the screening month, receiving UF and/or sodium profiling in routine HD prescription in the screening month, and intradialytic hypotension > 1 episode requiring session or ultrafiltration termination in the screening month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the changes in highly-sensitive troponin I level from pre-to post-dialysis during 4 dialysis sessions of constant ultrafiltration and 4 dialysis sessions of profiled ultrafiltration over 4 consecutive weeks, in patients of endstage renal disease with fluid overloadTimepoint: At timepoints 1-4 during week 1,2 (constant ultrafiltration) and timepoints 5-8 during week 3,4 (profiled ultrafiltration) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the occurrence of symptomatic intradialytic hypotension during 4 dialysis sessions of constant ultrafiltration and 4 dialysis sessions of profiled ultrafiltration over 4 consecutive weeks, in patients of endstage renal disease with fluid overloadTimepoint: At timepoints 1-4 in weeks 1,2 and timepoints 5-8 in weeks 3,4 | — |
Countries
India
Contacts
Public ContactShivani Kanwal
Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow
Outcome results
None listed