Health Condition 1: J45- Asthma
Conditions
Interventions
Intervention1: Vitamin D3 supplementation as add on to standard therapy: Vitamin D3: Oral powder 60,000 IU/week for 2 months
Standard therapy: Inhaled corticosteroids and beta 2 agonists
Control Inter
Sponsors
University of Health Sciences Rohtak
Eligibility
Inclusion criteria
Inclusion criteria: 1. Clinician diagnosed asthma 2. Baseline serum vitamin D levels 3. History of = 1 exacerbation in the last 12 months
Exclusion criteria
Exclusion criteria: 1. Chronic respiratory disorders other than asthma 2. Chronic oral corticosteroid therapy 3. Already on vitamin D supplementation 4. Unwillingness to participate in study
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| ? Change in pulmonary function test using spirometry.Timepoint: 0, 1, 2, 3, 4, 5 and 6 months;? Change in asthma control levels using GINA asthma control questionnaire (ACQ).Timepoint: 0,1,2,3,4,5,6 months;? Ability to achieve 50% reduction in inhaled corticosteroids (ICS) doseTimepoint: 0,1,2,3,4,5,6 months;? Average cumulative dose of ICSTimepoint: 6 months;? Change in quality of life using Asthma Quality of Life Questionnaire (AQLQ).Timepoint: 0 and 6 months;? Incidence of study withdrawals due to worsening asthma or treatment related adverse events.Timepoint: 6 months | — |
Primary
| Measure | Time frame |
|---|---|
| ?Association of different vitamin D receptor (VDR) SNPs with incidence and time to severe asthma exacerbations in two treatment arms.Timepoint: Baseline and 6 months | — |
Countries
India
Contacts
Public ContactDr Niti Mittal
PGIMS, Rohtak
Outcome results
None listed