To see effects of oral melatonin and oral zolpidem on blood pressure, heart rate in patients undergoing surgery under general anaesthesia.

Comparative efficacy of oral melatonin versus oral zolpidem for attenuation of hemodynamic response to intubation in adult patients undergoing elective surgeries.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/02/049527

Enrollment

150

Registered

2023-02-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Melatonin: Oral Melatonin 9 mg (3 tablets of 3 mg each) on the morning of surgery Control Intervention1: Zolpidem: oral zolpidem 5mg tablet on the morning of surgery

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled to undergo elective surgery. 2. American Society of Anaesthesiologist(ASA) physical status I/II 3. Age 20-60 years of either gender

Exclusion criteria

Exclusion criteria: 1. Patients with anticipated difficult airway and requiring >2 attempts and >15 seconds for intubation 2. Patients refusing to give Informed Consent 3.Pregnancy, history of mental illness, Bleeding diathesis, Severe cardiovascular, respiratory, hepatic or renal diseases 4. Receiving treatment with any of study drugs 5. Known allergy to study drugs 6. Morbid obesity (BMI >35 kg/m2)

Design outcomes

Primary

Measure	Time frame
To compare efficacy of oral melatonin versus oral zolpidem for attenuation of hemodynamic response (systolic blood pressure, diastolic blood pressure, mean blood pressure, heart rate) to intubation in adult patients undergoing elective surgeries.Timepoint: Baseline, 1 minute, 2 minutes, 3 minutes, 5 minutes, 10 minutes and 30 minutes	—

Secondary

Measure	Time frame
Total induction agent used intraoperative, Total opioid used intraoperative and adverse effects of drugTimepoint: Intraoperative, Intraoperative, Intraoperative and postoperative	—

Countries

India

Contacts

Public ContactDr Sanjeev Palta

Government Medical College and Hospital, Sector 32, Chandigarh

richajayant@rediffmail.com9646121513

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026