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EFFECT OF N-ACETYL CYSTEINE THERAPY ON ENZYME AFFECTING SPERM ACTIVITY IN SEMEN IN MALE INFERTILITY : A PILOT STUDY

EFFECT OF N-ACETYL CYSTEINE THERAPY ON PLATELET ACTIVATING FACTOR-ACETYL HYDROLASE ACTIVITY IN SEMEN IN MALE INFERTILITY : A PILOT STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049522
Enrollment
30
Registered
2023-02-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N46- Male infertility

Interventions

Intervention1: N-acetyl cysteine therapy: PAF-AH levels in semen will be checked before and N-acetyl cysteine therapy 600mg once a day for 3 months Control Intervention1: Not applicable: Not applicab

Sponsors

University college of medical sciences and guru teg Bahadur hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Males with 2 abnormal semen analysis reports at 2-3 weeks interval,of oligozoospermia and/or asthenozoospermia and not on any hormonal or antioxidant therapy

Exclusion criteria

Exclusion criteria: 1.Cases of azoospermia confirmed on 3 occasions. 2.Men with erectile or ejaculatory dysfunction or with inability to provide semen sample. 3.History of any febrile illness or surgery in the past 3 months. 4. Males with chronic medical disorder like diabetes,hypertension and tuberculosis

Design outcomes

Primary

MeasureTime frame
Comparison of seminal PAF-AH activity before and after NAC therapyTimepoint: 3 months—

Secondary

MeasureTime frame
1)Association of PAF-AH activity with semen parameters before and after NAC therapy. 2)Comparison of semen parameters before and after NAC therapy. 3) To assess the side effects of NAC,if any.Timepoint: 3 months—

Countries

India

Contacts

Public ContactJHALAK JAIN

UCMS and GTB HOSPITAL

dralpanasingh@gmail.com7042109290

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026