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To compare and evaluate the antimicrobial efficacy (in terms of bacterial load reduction) of combination of ozone oil with Chitosan Nano-particle and Double Antibiotic Paste as intracanal medicament in teeth requiring retreatment of previously done root canal therapy.

Comparative evaluation of antimicrobial efficacy of Combination of Ozone oil with Chitosan Nano-Particle and double antibiotic paste as intracanal medicament in Endodontic Retreatmentâ?? A randomized clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049482
Enrollment
32
Registered
2023-02-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K045- Chronic apical periodontitis Health Condition 3: K045- Chronic apical periodontitis Health Condition 4: K045- Chronic apical periodontitis Health Condition 5: K045- Chronic apical periodontitis Health Condition 6: K04- Diseases of pulp and periapical tissues

Interventions

Intervention1: Combination of Chitosan Nano-Particle with ozonated oil: Ozones strong biocompatibility and antiviral, antifungal, and antibacterial properties have led to its usage in the medical prof

Sponsors

Dr Harshit Mavani
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients, i.e., Class I patients according to American Society of Anaesthesiology [ASA] classification having multirooted teeth diagnosed with post treatment apical periodontitis will be included. Teeth indicated for endodontic retreatment will be included. A written informed consent will be taken from all the patients and only those patients ready to sign the consent form will be included in the study.

Exclusion criteria

Exclusion criteria: Patients who received antibiotic therapy within the previous 3 months Teeth with vertical root fracture Teeth with periodontal pockets deeper than 4 mm Teeth in which prosthesis could not be removed. Teeth with severe crown destruction Teeth with separated instrument Patients with known allergy to Shrimps/Chitosan

Design outcomes

Primary

MeasureTime frame
The result of this study will help us to know about the antibacterial efficacy of combination of ozone oil with chitosan nanoparticle as intracanal medicamentTimepoint: First sample will be taken at baseline. Second sample will be taken after a week (7 days)—

Secondary

MeasureTime frame
To know which has better antibacterial activity between combination of ozone oil with chitosan nanoparticle and double antibiotic pasteTimepoint: 7 days—

Countries

India

Contacts

Public ContactDr Kishan KV

K.M Shah Dental College and Hospital

drkishankv@yahoo.co.in8141787335

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026