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The effect of genetic mutations and resultant adverse side effects of Azathioprine and related drugs

Association of nucleoside diphosphate-like moiety X motif 15 (NUDT15) and thiopurine S-methyltransferase (TPMT) gene polymorphisms with adverse drug effects of azathioprine and related drugs - a retrospective study from a single tertiary care teaching hospital from Mumbai, India.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/02/049394
Enrollment
500
Registered
2023-02-01
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D899- Disorder involving the immune mechanism, unspecified

Interventions

Intervention1: Not Applicable: Not Applicable Control Intervention1: Not Applicable: Not Applicable

Sponsors

Seth GS Medical College & KEM Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Data of all patients who were on AZA who were referred to our lab for pharmacogenetic testing of NUDT 15 and TPMT since 2021 till current date

Exclusion criteria

Exclusion criteria: 1. Patients not on AZA or related drugs 2. Genotyping results of NUDT15 / TMPT not available for any reason

Design outcomes

Primary

MeasureTime frame
Association between NUDT and TMPT genotypes and adverse drug reactions with AZA or related drugsTimepoint: Day 0 (Baseline)—

Secondary

MeasureTime frame
NoneTimepoint: Not Applicable—

Countries

India

Contacts

Public ContactJeffrey Pradeep Raj

Seth GS Medical College and KEM Hospital

jpraj.m07@gmail.com7904286189

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026