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To evaluate the effect of topical ripasudil on post-operative corneal clarity following phacoemulsification surgery

To evaluate the effect of topical ripasudil hydrochloride hydrate [0.4%] and timolol maleate [0.5%] on corneal endothelium following phacoemulsification

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/02/049379
Enrollment
90
Registered
2023-02-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H598- Other intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified Health Condition 2: Z961- Presence of intraocular lens

Interventions

Intervention1: Topical ripasudil hydrochloride hydrate[0.4%] eye drops: Topical ripasudil hydrochloride hydrate[0.4%] eye drops twice a day for 1 month along with the routine care of management after

Sponsors

Dr.Soumya S Nair
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.AGE-40 years TO 90 years 2.Patients who have undergone phacoemulsification surgery by one of the 3 specific surgeons through clear corneal incision with in-the-bag intraocular lens and have certain predetermined parameters of cataract and intra operative findings are recruited immediately following surgery and eye pad opening 3.CDE 4.LOCS grade of cataract 5.Cases included in the study are those done by 3 specific surgeons 6.Preoperative corneal endothelial count- Above 1800 7.Preoperative NORMAL IOP[

Exclusion criteria

Exclusion criteria: 1. Corneal dystrophies and other opacities or diseases precluding routine surgery 2. Complicated cataract 3. Cataract associated with glaucoma 4. Detectable posterior segment lesions 6. Irregular follow up 7. Intraoperative additional instrumentation 8. Intraoperative complications like PCR, vitreous loss 9. Allergy to any of the drugs ( timolol maleate, ripasudil) 10.Bronchial Asthma 11.Any cardiac abnormalities 12.Any patient deemed unfit by the surgeon

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of topical ripasudil hydrochloride hydrate [0.4%] in the post-operative corneal clarity following phacoemulsificationTimepoint: Post-operative day 1-2; Post-operative day 7-14 ; Post-operative day 30-60—

Secondary

MeasureTime frame
To study post-operative corneal endothelial health including endothelial cell count and central corneal thickness following PhacoemulsificationTimepoint: Post-operative day 1-2; Post-operative day 7-14 ; Post-operative day 30-60—

Countries

India

Contacts

Public ContactKalakuntla Nihith Chandra

Kasturba Medical College and Kasturba hospital,Manipal,MAHE

soumya.nair@manipal.edu9446907831

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026