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To detect and to compare diabetic biomarker in saliva and blood of Periodontitis patients with and without Type 2 Diabetes Mellitus

Estimation and correlation of 1,5-Anhydroglucitol in saliva and serum of Periodontitis patients with and without Type 2 Diabetes Mellitus - A Cross Sectional Analytical study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2023/02/049363
Enrollment
90
Registered
2023-02-01
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications

Interventions

None listed

Sponsors

Self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Presence of minimum 20 natural teeth. Group 1 Patients diagnosed with Generalized periodontitis and Type 2 Diabetes Mellitus. Group 2 Patients diagnosed with Generalized Periodontitis who are normoglycemic. Group 3 Healthy controls.

Exclusion criteria

Exclusion criteria: 1 Patients with any other systemic disease accompanying Type 2 DM. 2 Patients with Type 1 DM. 3 Patients who are obese (BMI >30) 4 Current or former smokers. 5 Pregnant women. 6 Patients with any intra oral lesions and unrestored caries. 7 Patients with history of periodontal therapy within past 6 months. 8 Patients with history of antibiotic intake within past 3 months. 9 Patients with history of anti-inflammatory drug therapy within 3 months. 10 Patients taking any others medications excluding medication for DM. 11 Patients taking SGLT-2 inhibitor (SGLT-2i treatment can interfere with the measurement of 1,5-AHG, resulting in a falsely low value in patients with controlled blood glucose levels).

Design outcomes

Primary

MeasureTime frame
Salivary 1,5-AHG levels Serum 1,5-AHG levels FBS PPBS HbA1cTimepoint: Baseline—

Secondary

MeasureTime frame
Plaque index Gingival index Bleeding on probing Probing pocket depth Clinical attachment lossTimepoint: Baseline—

Countries

India

Contacts

Public ContactDr Nisha KJ

Vydehi Institute of Dental Sciences and Research Centre

nisharejath@gmail.com8105490909

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026