Health Condition 1: O- Medical and Surgical Health Condition 2: K631- Perforation of intestine (nontraumatic)
Conditions
Interventions
Intervention1: To study effects of invasive ventilatory mode- APRV (Airway pressure release ventilation) in surgical patients in ICU: To study ventilatory, hemodynamic, and arterial blood gas paramet
Sponsors
Director Principal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients on invasive mechanical ventilation and admitted in ICU following exploratory Laparotomy due to acute respiratory failure (ARF) for less than 24 hours 2. Age group 18-60 years 3. Stable hemodynamic parameters (Mean Arterial Pressure between 70 mm Hg and 100 mm Hg, heart rate between 60 and 100/minute, SPO2 >= 90%) 4. Richmond Agitationâ??Sedation Scale (RASS) between 0 and -2
Exclusion criteria
Exclusion criteria: 1. Pregnant and morbidly obese patients (BMI >35) 2. Patient diagnosed with acute respiratory distress syndrome (ARDS) (Mild, Moderate, or Severe) according to Berlinâ??s definition. 3. Patients with severe or chronic heart, lung, hepatic or renal disease 4. Patients with severe neuromuscular disorders 5. Patient on vasopressors, cardiac depressants or neuromuscular blockers 6. Patient with traumatic brain injury 7. Patient with blunt or traumatic chest injury 8. Patients with severe multiple organ dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilatory parameters: Peak airway pressure (Ppeak), plateau pressure (Pplat), mean airway pressure (Pmean), compliance (C), static compliance (Cstat), airway resistance (Raw) will be recordedTimepoint: T1-2 hours after keeping the patient on A/C VCV for 2 hours (washing period). T2-2 hours after shifting on A/C VC mode from its original mode of ventilation (corresponding to time just before switching to study ventilatory mode). T3-4 hours after shifting on study mode (APRV or PRVC) as per group allocation. T4-6 hours after shifting on study mode (APRV or PRVC) as per group allocation. T5-8 hours after shifting on study mode (APRV or PRVC) as per group allocation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial Blood Gas parameters: pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), and arterial oxygen saturation percentage (SaO2)Timepoint: T1-2 hours after keeping the patient on A/C VCV for 2 hours (washing period). T2-2 hours after shifting on A/C VC mode from its original mode of ventilation (corresponding to time just before switching to study ventilatory mode). T3-4 hours after shifting on study mode (APRV or PRVC) as per group allocation. T4-6 hours after shifting on study mode (APRV or PRVC) as per group allocation. T5-8 hours after shifting on study mode (APRV or PRVC) as per group allocation.;Hemodynamic parameters: Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), end-tidal carbondioxide (EtCO2), percentage of oxygen saturation by pulse oximetry (SpO2), ratio of oxygen saturation to fraction of inspired oxygen (SPO2/FIO2) and urine output will be recordedTimepoint: T1-2 hours after keeping the patient on A/C VCV for 2 hours (washing period). T2-2 hours after shifting on A/C VC mode from its original mode of ventilation (corresponding to time just before switching to study ventilatory mode). T3-4 hours after shifting on study mode (APRV or PRVC) as per group allocation. T4-6 hours after shifting on study mode (APRV or PRVC) as per group allocation. T5-8 hours after shifting on study mode (APRV or PRVC) as per group allocation. | — |
Countries
India
Contacts
Public ContactDr Jasmine Kaur Narula
Government Medical College and Hospital
Outcome results
None listed