Benefit of different drug combinations in decreasing pain during and after gall bladder removal surgery

Comparison of intravenous Magnesium-Lignocaine or Magnesium-Lignocaine-Ketorolac versus normal saline for perioperative pain in laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/01/049236

Enrollment

120

Registered

2023-01-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K80- Cholelithiasis

Interventions

Intervention1: Intravenous Magnesium-Lignocaine-Ketorolac: 50 mg.kg-1 Magnesium sulphate, 1.5 mg.kg-1 Lignocaine and 0.5 mg.kg-1 Ketorolac diluted to 10 mL with Normal saline. Intervention2: Intraven

Eligibility

Inclusion criteria

Inclusion criteria: 1. Body mass index (BMI): 18-35 kg.m-2 2. Patients having American Society of Anaesthesiologists (ASA) Grade I-II 3. Patients scheduled to undergo laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: 1. Cardiac conduction abnormalities and congestive heart failure 2. Renal or hepatic impairment 3. Neurological disorders 4. Pregnant and lactating women 5. Patients not able to understand VAS 6. History of substance abuse 7. Contraindications to study drugs: lignocaine, ketorolac, magnesium 8. Chronic pain conditions, neurodegenerative or autoimmune disorders

Design outcomes

Primary

Measure	Time frame
Pain at rest and movementTimepoint: baseline, post extubation, in postoperative care unit (PACU), at1, 6, 8, 12 and 24 h postoperatively.	—

Secondary

Measure	Time frame
Length of hospital admissionTimepoint: Time of discharge;Serum lactate levels and ABG parametersTimepoint: baseline before surgery, intraoperative before extubation, postoperative at 6 h and 24 h;Time to first rescue analgesiaTimepoint: time of first drug intake in 24 h;Total intraoperative morphine used, time to first rescue and total analgesia in PACU and in postoperative periodTimepoint: 24 hours;adverse effectsTimepoint: during entire duration of study;Haemodynamic parameters (PR, BP, RR)Timepoint: baseline, at time of induction, after intubation, every 10 minutes during surgery, at time of extubation, every 5 minutes for 15 minutes, then every 15 minutes up to 60 minutes in PACU, and at 6, 8 ,12 and 24 hours	—

Measure

Time frame

Length of hospital admissionTimepoint: Time of discharge;Serum lactate levels and ABG parametersTimepoint: baseline before surgery, intraoperative before extubation, postoperative at 6 h and 24 h;Time to first rescue analgesiaTimepoint: time of first drug intake in 24 h;Total intraoperative morphine used, time to first rescue and total analgesia in PACU and in postoperative periodTimepoint: 24 hours;adverse effectsTimepoint: during entire duration of study;Haemodynamic parameters (PR, BP, RR)Timepoint: baseline, at time of induction, after intubation, every 10 minutes during surgery, at time of extubation, every 5 minutes for 15 minutes, then every 15 minutes up to 60 minutes in PACU, and at 6, 8 ,12 and 24 hours

—

Countries

India

Contacts

Public ContactGeetika Sen

Government Medical College and Hospital, Chandigarh

vanitaanupam@yahoo.co.in9646121649

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026