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Comparison of dexmedetomidine, esmolol and combination of both drugs to decrease stress response to intubation.

Comparison of effect of intravenous Dexmedetomidine, Esmolol and combination of Esmolol and Dexmedetomidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/049139
Enrollment
63
Registered
2023-01-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: Z00-Z99- Factors influencing health status and contact with health services

Interventions

Intervention1: Attenuation of hemodynamic stress response to Laryngoscopy and Endotracheal Intubation by drugs: Comparison of effect of intravenous Dexmedetomidine. Esmolol and combination of Esmolol

Sponsors

ABVIMS AND DR RML HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of Anaesthesiologists(ASA) Physical status I and II Patients 2. Either sex 3. Age: 20 to 50 years 4. Elective surgical procedures

Exclusion criteria

Exclusion criteria: 1. Known sensitivity to any study drug 2. Pregnant females 3. Patient with chronic hypertension and diabetes mellitus 4. Patient with history of cardiac or respiratory disease 5. Patient with anticipated difficult airway 6. Patient with impaired kidney or liver function 7. Patient on Beta blockers

Design outcomes

Primary

MeasureTime frame
Hemodynamic response to Laryngoscopy and Endotracheal Intubation(HR,SBP,DBP,MAP)Timepoint: Baseline(at arrival in OT) 1 minute after Laryngoscopy and Endotracheal Intubation 3 minutes after Laryngoscopy and Endotracheal Intubation 5 minutes after Laryngoscopy and Endotracheal Intubation—

Secondary

MeasureTime frame
Biochemical markers of stress response(Serum cortisol and Blood glucose levels)Timepoint: Baseline(at arrival in OT) 5 minutes after Laryngoscopy and Endotracheal Intubation—

Countries

India

Contacts

Public ContactDr Shireen Singh

ABVIMS AND DR RML HOSPITAL

lalitachaudhary055@gmail.com9968299710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026