Health Condition 1: N119- Chronic tubulo-interstitial nephritis, unspecified
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Dr Namrata Rao S
Eligibility
Inclusion criteria
Inclusion criteria: Exclusion of all known causes of CKD as per protocol (described) Mandatory criteria: eGFR < 60 ml/min/1.73 m2 by CKD-EPI formula + ultrasonography (USG) showing small shrunken kidneys and/or Renal biopsy done shows chronic tubulointerstitial nephritis with no immune deposits + No exclusion criteria (detailed below)
Exclusion criteria
Exclusion criteria: Stable patients attending Nephrology OPD and diagnosed with chronic kidney disease (CKD) as per the KDIGO criteria definition, are enrolled in the hospital CKD registry. Etiologic workup for cause of CKD would be done as per institutional protocol which is as follows (upon which patient will be excluded): a.) Diabetic kidney disease: Diabetes mellitus identified using American Diabetes Association (ADA) criteria for fasting and postprandial blood glucose levels or if the patient has been receiving hypoglycemic agents and has fundus findings of diabetic retinopathy alongwith proteinuric kidney disease (urinary protein excretion of > 1.5 g/day or dipstick value of ++ or more), or has renal biopsy findings of diabetic nephropathy, will be presumed to have diabetic kidney disease. b.) Hypertensive nephrosclerosis: CKD will be attributed to hypertensive nephrosclerosis if the patient had documented systemic hypertension for >5 years before the diagnosis of CKD or with severe hypertension (requiring more than 2 antihypertensives or blood pressure >160/100 mm Hg) or fundus findings of chronic hypertensive retinopathy at any time in the absence of other causes of CKD. c.) Chronic glomerulonephritis: Chronic glomerulonephritis will be diagnosed if kidney biopsy shows evidence of glomerulonephritis or if a patient with CKD had a history of long-standing edema and/or proteinuria > ++ or >1.5 g/day. d.) Chronic tubulointerstitial nephritis: The diagnosis of chronic tubulointerstitial disease will be made either on histology or based on a compatible history, the presence of vesicoureteral reflux, and/or recurrent urinary tract infection. e.) Others: Obstructive uropathy, renal stone diease, and cystic disease will be diagnosed if there are confirmatory findings seen on imaging studies. The diagnosis of renovascular disease will be made from Doppler study or angiography. Kidney disease in association with specific â??syndromesâ?? will be diagnosed by characteristic clinical findings, family history, and laboratory abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To estimate the prevalence of chronic kidney disease of undetermined etiology (CKDu) among the patients visiting the hospital in a time period of 2 yearsTimepoint: Baseline (cross-sectional study) | — |
Secondary
| Measure | Time frame |
|---|---|
| To localize cases of CKDu according to village, Tehsil and district to identify disease clusters, if anyTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactNamrata Rao S
Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow
Outcome results
None listed