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which drug reduces preoperative anxiety

A comparative study of melatonin and gabapentin in reducing preoperative anxiety

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/049073
Enrollment
70
Registered
2023-01-18
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes

Interventions

Intervention1: Melatonin: melatonin tablet 6 mg to be swallowed Orally preoperatively 30 minutes prior to surgery Duration of therapy: 30 minutes prior to surgery Control Intervention1: alprazolam: 0

Sponsors

AIIMS New delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: PAtients undergoing routine surgery after trauma ASA I and asa II patients

Exclusion criteria

Exclusion criteria: a) Patients for emergency surgeries b) Surgeries taking place after 1pm (to account for diurnal variation in cortisol levels) c) Patients having altered mental state, history of psychiatric disorder, history of drug abuse or those on chronic pain medication

Design outcomes

Primary

MeasureTime frame
Difference in the change in VAS anxiety scoreTimepoint: Difference in the change in VAS anxiety score at 90 minutes after drug administration—

Secondary

MeasureTime frame
Change in IL6 and serum cortisol levelsTimepoint: 90 minutes post drug administration—

Countries

India

Contacts

Public ContactKelika Prakash

Department of anaesthesiology AIIMS

kelika.prakash@gmail.com09540947117

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026