Health Condition 1: C060- Malignant neoplasm of cheek mucosa Health Condition 2: C050- Malignant neoplasm of hard palate Health Condition 3: C062- Malignant neoplasm of retromolar area
Conditions
Interventions
Intervention1: Dexmedetomidine: Dexmedetomidine loading dose of 0.8mcg/kg over 10mins
Maintenance dose of 0.5mcg/kg/hr
Control Intervention1: Magnesium sulphate: 50mg/kg magnesium sulphate loading do
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: 1.ASA 1 and 2 2.patients undergoing elective mandibulectomy or maxillectomy surgery
Exclusion criteria
Exclusion criteria: 1.patient refusal 2.history of allergy to study drug 3.patients on calcium channel blockers, beta blockers,ACE inhibitors, anticoagulant 4.h/o CVA,IHD,COPD 5.impaired renal function test, impaired liver function test. 6.preop HR of less than 45/min, second or third degree heart block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of study drugs on Hemodynamic parameters like blood pressure and heart rate IntraoperativelyTimepoint: 1.baseline 2.before induction (after bolus) 3.15mins after induction 4.30mins after induction 5. 45mins after induction 6.60mins after induction 7.90mins after induction 8.120mins after induction 9.150mins after induction 10.180mims after induction 11.210mins after induction 12.240mins after induction | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.adverse effects of study drugs 2.postoperative sedation assessment using Ramsay sedation scoreTimepoint: 1.5mins before extubation 2.5mins in PACU 3.10mins in PACU 4.15mins in PACU 5.30mins in PACU 6.60mins in PACU 7.90mins in PACU 8.120mins in PACU 9.150mins in PACU 10.180mins in PACU 11.210mins in PACU 12.240mins in PACU | — |
Countries
India
Contacts
Public ContactPoojashree
Kidwai memorial institute of oncology bangalore
Outcome results
None listed