Health Condition 1: J960- Acute respiratory failure
Conditions
Interventions
Intervention1: Intravenous magnesium sulphate: Single dose of IV magnesium sulphate infusion 50 mg/kg over 30 minutes
Control Intervention1: Intravenous aminophylline: IV aminophylline infusion as per
Sponsors
Surya Mother and Child Superspeciality hospital
Eligibility
Inclusion criteria
Inclusion criteria: All children between 2- 16 years of age with moderate to severe acute asthma defined as PRAM (Pediatric respiratory assessment measure) score > 5 inspite of first line therapy with short acting beta agonists and corticosteroids.
Exclusion criteria
Exclusion criteria: 1. First episode of wheezing or alternative diagnosis like foreign body aspiration. 2. Coexisting pneumonia defined as radiological abnormalities like infiltrates or opacities on chest Roentgenogram. 3. Patients needing ventilator support. 4. Patients who have underlying cardiac, renal, neurologic or pulmonary dysfunction contraindicating the use of magnesium sulphate or aminophylline 5. Known hypersensitivity to Magnesium sulphate or aminophylline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Reduction in asthma severity as measured by PRAM (Pediatric Respiratory Assessment Measure) score at 60 mins, 120 mins and 4 hours, 6 hrs, 12 hours and 24 hours after initiating therapy.Timepoint: 1. Reduction in asthma severity as measured by PRAM (Pediatric Respiratory Assessment Measure) score at 60 mins, 120 mins and 4 hours, 6 hrs, 12 hours and 24 hours after initiating therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| a. Length of ICU stay b. Duration of oxygen support c. Need for NIV d. Need for HFNC e. Need for invasive mechanical f. Mortality g. Adverse events such as tachycardia, GI bleeding, vomiting, need for vasoactive agents Timepoint: whole length of hospital stay | — |
Countries
India
Contacts
Public ContactDr Pratik Sonje
Surya Mother and Child Superspeciality hospital, Pune
Outcome results
None listed