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comparison of 3 medicine and 2 medicines for prevention of vomiting after surgery.

Comparison of Aprepitant, Dexamethasone and Ondansetron with Dexamethasone and Ondansetron for prevention of post operative nausea vomiting in high risk patients undergoing laparoscopic surgeries. A Randomised control trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/049005
Enrollment
200
Registered
2023-01-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Aprepitant: Adding Tab Aprepitant 80mg Orally 2 Hours Prior to Surgery to Inj Dexamethasone 8mg IV given at Induction and Inj Ondansetron 4 mg Given prior to Extubation as Prophylaxis i

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: FEMALE >18 YRS,NON SMOKERS UNDERGOING LAPAROSCOPIC SURGERY LASTING 2-4 HOURS, RECEIVING INTRAOPERATIVE AND POSTOPERATIVE OPIOID ANALGESIA.

Exclusion criteria

Exclusion criteria: 1. CONSUMPTION OF AN AGENT WITH ANTI EMETIC PROPERTIES WITHIN 24 HRS PRIOR TO COMMENCEMENT OF THE STUDY. 2. KNOWN HYPERSENSITIVITY TO APREPITANT, ONDANSETRON OR DEXAMETHASONE. 3. PREGNANCY. 4. PATIENTS REQUIRING POSTOPERATIVE MECHANICAL VENTILATION. 5. SURGERY LASTING >4 HRS 6. TIVA 7. PATIENTS NOT GIVING CONSENT.

Design outcomes

Primary

MeasureTime frame
TO COMPARE THE INCIDENCE OF POSTOPERATIVE NAUSEA AND VOMITING.Timepoint: 2 HOURS AND 24 HOURS FOLLOWING SURGERY.—

Secondary

MeasureTime frame
TIME TO FIRST RESCUE ANTIEMETIC AND THE AMOUNT OF ANTIEMETIC CONSUMED.Timepoint: FIRST 24 HOURS.—

Countries

India

Contacts

Public ContactShalini Bala

AIIMS JODHPUR

pk_bhatia@yahoo.com9829159665

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026